carol greider lab mice

Carolyn Widney "Carol" Greider (born April 15, 1961) is an American molecular biologist and Nobel laureate. As a graduate student, he investigated mouse models of telomere dysfunction in Carol Greider’s laboratory. We use biochemistry, yeast and mice to examine telomere function. Carol Greider discovered the answer in graduate school at the University of California, Berkeley while working in the lab of Elizabeth Blackburn, who shares her Nobel Prize in Physiology or Medicine. It's entirely possible that Greider should have made Bret middle author or at least acknowledged him because it was his idea. Carol Greider, Ph.D. received her bachelor’s degree from the University of California at Santa Barbara in 1983 and a Ph.D. in 1987 from the University of California at Berkeley. We generated telomerase null mice that are viable and show progressive telomere shortening for up to six generations. These mice show unusual longevity for a mouse species, averaging between 5 and 7 years (). Throughout her career, she has been a leading researcher in telomerase biochemistry, telomere function, and the critical roles that telomeres serve, including maintaining genome stability, preventing cancer, and modulating senescence and aging.

C57BL/6, 129/SvJ, FVB/NJ, SPRET/Ei and CAST/Ei mice were obtained from the Jackson Laboratory. As a graduate student, he investigated mouse models of telomere dysfunction in Carol Greider’s laboratory. Telomerase and telomere function. Carol Greider, Ph.D., Johns Hopkins School of Medicine. Bret Weinstein brought up a concern about telomere length in lab mice vs wild mice to Carol in 1998, and Carol did not follow up (or buried it) and undermined cancer research.

Greider then completed her postdoctoral work, and also held a faculty position, at the Cold Spring Harbor Laboratory, Long Island, New York. View Carol Greider’s profile on LinkedIn, the world's largest professional community. See the complete profile on LinkedIn and discover Carol… Greider discovered telomerase as a graduate student in Elizabeth Blackburn’s laboratory at UC Berkeley. About Carol W. Greider Carol Greider, Ph.D. received her bachelor's degree from the University of California at Santa Barbara in 1983 and a Ph.D. in 1987 from the … My lab is focused understanding telomerase and cellular and organismal consequences of telomere dysfunction. She was also able to reconstitute Tetrahymena telomerase in vitro (1994) and define the mechanisms of template utilizatio… So the issue of long telomeres on C57 mice from Jax is just another on a long list of caveats to research done in mice. carol greider. In the later generations, when telomeres are short, cells die via apoptosis or senescence.

Crosses of Greider continued to study Tetrahymena telomerase, cloning the gene encoding the RNA component and demonstrating that it provided the template for the TTGGGG telomere repeats (1989) as well as establishing that telomerase is processive (1991). Carol Greider. 05:48 lab mice have extremely long telomeres but are short-lived. Just before Greider’s arrival Professor and Director ... My lab is focused on understanding telomerase and cellular and organismal consequences of telomere dysfunction. 3). My lab is focused understanding telomerase and cellular and organismal consequences of telomere dysfunction. Telomeres are essential for both chromosome stability and for length maintenance. Academic Pettiness & Possible Theft A colleague of Bret’s, Carol Greider —who helped conduct research for his paper on lab mice telomere length, actually scrutinized it when Bret attempted to have it published, as she didn’t want the paper to go mainstream Even when Carol Greider later wrote a paper on elongated lab mouse telomeres, taking complete ownership of the idea to study this as her own, she ignored the whole aspect of how this finding might compromise previous medical study data using mice, and …

The lab has generated telomerase null mice that are viable and show progressive telomere shortening for up to six generations. Livers from Mus musculus denmark, Mus musculus castaneus, Mus hortulanus, Mus macedonicus and Mus caroli inbred mouse livers were kindly provided by the Chapman laboratory at the Roswell Park Cancer Institute.Peromyscus leucopus livers were kindly provided by … In the later generations, when telomeres are short, cells die via apoptosis or senescence. Carol Greider was a graduate student of Dr. Blackburn's at the University of … The TRF distributions from these wild-derived strains were The mice that researchers around the US were using to produce their experiments were not wild mice but rather lab bred mice from one source.

All I have is Bret's word there. We have developed a mouse model to study this disease. We use biochemistry, yeast and mice to examine telomere function.

We generated telomerase null mice that are viable and show progressive telomere shortening for up to six generations.